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题名: Smart Plasmonic Glucose Nanosensors as Generic Theranostic Agents for Targeting-Free Cancer Cell Screening and Killing
作者: Chen,Limei; Li,Haijuan; He,Haili; Wu,Haoxi; Jin,Yongdong
刊名: ANALYTICAL CHEMISTRY
出版日期: 2015
卷号: 87, 期号:13, 页码:6868-6874
关键词: CONTRAST AGENTS ; GOLD NANOCAGES ; NANOPARTICLES ; NANOSHELLS ; THERAPY ; PET ; TOMOGRAPHY ; BIOMARKERS ; NANORODS ; DESIGN
通讯作者: Jin,YD
文章类型: 期刊论文
英文摘要: Fast and accurate identification of cancer cells from healthy normal cells in a simple, generic way is very crucial for early cancer detection and treatment. Although functional nanoparticles, like fluorescent quantum dots and plasmonic Au nanoparticles (NPs), have been successfully applied for cancer cell imaging and photothermal therapy, they suffer from the main drawback of needing time-consuming targeting preparation for specific cancer cell detection and selective ablation. The lack of a generic and effective method therefore limits their potential high-throughput cancer cell preliminary screening and theranostic applications. We report herein a generic in vitro method for fast, targeting-free (avoiding lime-consuming preparations of targeting moiety for specific cancer cells) visual screening and selective killing of cancer cells from normal cells, by using glucose-responsive/-sensitive glucose oxidase-modified Ag/Au nanoshells (Ag/Au-GOx NSs) as a smart plasmonic theranostic agent. The method is generic to some extent since it is based on the distinct localized surface plasmon resonance (LSPR) responses (and colors) of the smart nanoprobe with cancer cells (typically have a higher glucose uptake level) and normal cells.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000357839700066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ciac.jl.cn/handle/322003/64840
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Recommended Citation:
Chen,Limei,Li,Haijuan,He,Haili,et al. Smart Plasmonic Glucose Nanosensors as Generic Theranostic Agents for Targeting-Free Cancer Cell Screening and Killing[J]. ANALYTICAL CHEMISTRY,2015,87(13):6868-6874.
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